From the Wiki, TypoScript is a descriptive meta-language which defines how a website is rendered in TYPO3. Strictly speaking, it is a configuration language, which is purely declarative. It is known to bring a lot of power and benefit when it comes to customizing the CMS. However, everyone agrees, it has a rather steep learning curve. In the Bootstrap Package, aiming to encourage the use of TYPO3 CMS, it has very limited TypoScript in play which makes it easier to get started. Everything is at a central place and is rendered through Fluid Viewhelper.

However, TypoScript is definitely possible. Content can be connected by the means of a cObject Fluid for rendering objects. For more help, consult this resource.  

<f:cObject typoscriptObjectPath="lib.breadcrumb" />. 

Also a TS variable could be retrieved and transmitted to a View Helper. For more help, check out its usage

# The "XML" syntax
<v:var.typoscript path="foo">

# The shorthand syntax typically in a nested structure. Check example below 
{v:var.typoscript(path: 'lib.disqus.display')}

Consider the condition where an item should be rendered only for certains page branches:

# Condition in TypoScript. "82" corresponds to a page id.
[PIDupinRootline = 82]
    lib.disqus.display = 1
    lib.disqus.display = 0

# In a Fluid Template
<f:if condition="{v:var.typoscript(path: 'lib.disqus.display')}">
     <f:render section="Disqus" partial="Disqus" optional="TRUE" arguments="{_all}"/>